Myles Miller has been professionally involved with the research into the Indigenous cultures of southern New Mexico and Trans-Pecos Texas since returning to El Paso upon completion of graduate school in 1983. During the past 40 years, he has conducted research throughout the region and has participated in numerous excavations of pre-Hispanic and historic Native American settlements in southern New Mexico, west Texas, and southeastern Arizona. His current research interests involve the relationships between Indigenous social organization, ritual, landscapes, and ceramic and rock art iconography; chronometrics and chronology; and chemical compositional analysis. He presently serves as a Principal Investigator with Versar (formerly Geo-Marine, Inc.) and is currently supervising archeological work for the Bureau of Land Management, Fort Bliss Military Installation, White Sands Missile Range, and the Texas Department of Transportation.

He has published numerous chapters in edited volumes and conference proceedings volumes as well as over sixty reports describing the results of excavation projects. He is co-editor (with Charles Koenig) of the volume Earth Ovens and Desert Lifeways:  10,000 Years of Indigenous Cooking in the Arid Landscapes of North America (The University of Utah Press, 2023). He was awarded the 2018 Award of Excellence in Cultural Resource Management by the Society for American Archaeology for his contributions to understanding the prehistory of southern New Mexico and west Texas and his contributions to cultural resource management practices.